Table 1.

Class E Vps proteins and Complexes

Complex	Yeast protein	Human protein	Motifs	Binds to
Vps27-Hse1 complex	Vps27	HRS	UIM, FYVE, VHS	Ubiquitin, PI(3)P, ESCRT-II (Vps23)
	Hse1	STAM1, STAM2	UIM, VHS, SH3	Ubiquitin
ESCRT-I complex	Vps23	TSG101	UEV	Ubiquitin, Vps27
	Vps28	VPS28
	Vps37	VPS37A, B, C, D	Coiled-coil
ESCRT-II complex	Vps22	EAP30	Coiled-coil
	Vps25	EAP25		ESCRT-III (Vps20)
	Vps36	EAP45	GLUE, NZF	Ubiquitin
ESCRT-III complex	Vps2/Did4	CHMP2A, B	Charged, Coiled-coil
	Vps20	CHMP6	Charged, Coiled-coil	ESCRT-II (Vps25)
	Vps24	CHMP3	Charged, Coiled-coil
	Snf7/Vps32	CHMP4A, B, C	Charged, Coiled-coil
Vps4 complex	Vps4	VPS4A, B	AAA ATPase, Coiled-coil	ESCRT-III
Other MVB Proteins	Bro1/Vps31	ALIX/AIP1	Charged, Coiled-coil	LBPA, Doa4, ESCRT-III
	Vps60/Mos10	CHMP5	Charged, Coiled-coil	ESCRT-III
	Fti1/Did2	CHMP1A, B	Charged, Coiled-coil	ESCRT-III
	Vta1	LIP5		Vps4
	Vps44/Nhx1	SLC9A6	Sodium/Proton Exchanger