TABLE 3.
Sequences of HLA class I-restricted LMP1 epitopes in EBV isolates from Caucasian, African, Chinese, Papua New Guinean, and Indonesian individualsa
| Virus origin | Epitope sequence | HLA restriction | No. of isolates |
|---|---|---|---|
| B95.8 | GCC CIC CTT GTC CTC TAT TCC TTT GCT | ||
| ALLVLYSFA | HLA A2 | ||
| Caucasian | --------------------------- | 4 | |
| - - - - - - - - - | |||
| --G------------------------ | 1 | ||
| - - - - - - - - - | |||
| African | --------------------------- | 2 | |
| - - - - - - - - - | |||
| S.E. Asian (Spon) | --G------------------------ | 4 | |
| - - - - - - - - - | |||
| S.E. Asian (NPC) | --G------------------------ | 14 | |
| - - - - - - - - - | |||
| Papua New Guinean | --A--- T-G--------- G-------- | 7 | |
| - - - - - - A - - | |||
| --G--------------- G-------- | 1 | ||
| - - - - - - A - - | |||
| B95.8 | ATT GCT CTC TAT CTA CAA CAA AAC TGG | ||
| IALYLQQNW | HLA B57 and B58 | ||
| Caucasian | --------------------------- | 10 | |
| - - - - - - - - - | |||
| -----------------C--------- | 1 | ||
| - - - - - H - - - | |||
| African | --------------------------- | 2 | |
| - - - - - - - - - | |||
| S. E. Asian (Spon) | --------------------------- | 4 | |
| - - - - - - - - - | |||
| S. E. Asian (NPC) | --------------------------- | 14 | |
| - - - - - - - - - | |||
| C-------------------------- | 1 | ||
| L - - - - - - - - | |||
| Papua New Guinean | --------------------------- | 10 | |
| - - - - - - - - - | |||
| --------------------C------ | 1 | ||
| - - - - - - H - - | |||
| B95.8 | TAC TTA TTG GAG ATG CTC TGG CGA CTT | ||
| YLLEMLWRL | HLA A2 | ||
| Caucasian | -----C--------T------------ | 1 | |
| - F - - I - - - - | |||
| --------------------------- | 5 | ||
| - - - - - - - - - | |||
| -----C--------T------ G-G--- | 4 | ||
| - F - - I - - G - | |||
| --------------T------------ | 1 | ||
| - - - - I - - - - | |||
| African | --------------T------------ | 2 | |
| - - - - I - - - - | |||
| S.E. Asian (Spon) | -----C--------T--------G--- | 3 | |
| - F - - I - - - - | |||
| -----C-----C--T--------G--- | 1 | ||
| - F - I - - - - | |||
| S.E. Asian (NPC) | -----C--------T--------G--- | 15 | |
| - F - - I - - - - | |||
| Papua New Guinean | -----C--------T--------G--- | 4 | |
| - F - - I - - - - | |||
| -----C-----A--T--------G--- | 6 | ||
| - F - - I - - - - | |||
| --- C-- A-------T------------ | 1 | ||
| - - M - I - - - - | |||
| B95.8 | TAT CTA CAA CAA AAC TGG TGG ACT CTA | ||
| YLQQNWWTL | HLA A2 | ||
| Caucasian | --------------------------- | 10 | |
| - - - - - - - - - | |||
| --------C------------------ | 1 | ||
| - - H - - - - - - | |||
| African | --------------------------- | 2 | |
| - - - - - - - - - | |||
| S.E. Asian (Spon) | --------------------------- | 4 | |
| - - - - - - - - - | |||
| S.E. Asian (NPC) | --------------------------- | 15 | |
| - - - - - - - - - | |||
| Papua New Guinean | --------------------------- | 10 | |
| - - - - - - - - - | |||
| -----------C--------------- | 1 | ||
| - - - H - - - - - |
a
Boldface indicates CTL epitope sequence from prototype B95.8 isolate.