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. 2003 Jul;23(13):4449–4460. doi: 10.1128/MCB.23.13.4449-4460.2003

FIG. 7.

FIG. 7.

A model for sequential protein assembly and intracellular trafficking of pre-60S particles. Early pre-60S particles formed in the nucleolus contain Mak11, Ssf1, and Rlp24. The arrival of Nog1 is probably concomitant with Mak11 dissociation. After 27SA2-to-27SB processing, Nog2 associates with pre-60S concomitantly or after Ssf1 has left the particles. Late complexes containing Nog1, Nog2, and Rlp24 are transported to the nucleoplasm, where Nog1 and Nog2 dissociate, apparently before export to the cytoplasm. Finally, Rlp24 dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, Rpl24.