FIG. 2.

Hydrophobic interactions in the core of AS-48. The hydrophobic side chains in the core are shown in grey (helices 1 to 4) and pink (helix 5) and labeled with residue numbers and single-letter amino acid codes. The importance of the side chains of helix 5 is clear from the extensive interactions with most other regions of the core. The compactness of the fold is highlighted by the fact that all of the residues shown here have less than 20% of their side chain surfaces exposed to the solvent. View b is rotated 90° around the y axis in relation to a.