Table 3.
Major histocompatibility complex class II associations with autoantibodies seen in patients with SSc
| Autoantibodies | HLA association | Comments | References |
| ACA | HLA-DRB1 | ||
| DRB1*01 | In Hispanics and Caucasians | [53-55] | |
| DRB1*04 | |||
| HLA-DQB1 | |||
| DQB1*05 | [53,55] | ||
| Anti-Scl-70 | HLA-DRB1 | ||
| DRB1*1101 | In Caucasians and African Americans | [53-55] | |
| DRB1*1104 | In Japanese | [53,55] | |
| DRB1*1502 | In Hispanics and Caucasians | [55,136] | |
| HLA-DQB1 | |||
| DQB1*0301 | [71] | ||
| DQB1*0601 | |||
| HLA-DPB1 | |||
| DPB1*1301 | In Caucasians | [55] | |
| DPB1*0901 | In Japanese | [136] | |
| Anti-PM-Scl | HLA-DQA1*0501 | Not seen in Japanese | [54,80] |
| HLA-DRB1*0301 | |||
| Anti-Th/To | HLA-DRB1*11 | [87] | |
| Anti-RNAP | HLA-DQB1*0201 ? | [91,93] | |
| No association | |||
| Anti-U1-RNP | HLA-DR2 | In Japanese and Caucasians | [117] |
| HLA-DR4 | |||
| HLA-DQw5 | In African Americans | [118] | |
| DQA1*0101 | |||
| DQB1*0501 | |||
| HLA-DQw8 | |||
| DQB1*0302 | |||
| Anti-U3-RNP/antifibrillarin antibodies | HLA-DQB1*0604 ? | [91,93] | |
| No association |
Question marks denote associations seen in one study but not confirmed elsewhere. ACA, anti-centromere antibodies; HLA, human leukocyte antigen; RNP, ribonucleoprotein.