Table 1.

Biological activities of ADAMTSs

Enzyme	Substrate	Activity	Reference
ADAMTS-1	Aggrecan, versican, α2-macroglobulin	Cleavage of proteoglycan core proteins, anti-angiogenic	[25,45,50,51]
ADAMTS-2	Procollagen I, procollagen II	Processing of N-propeptide of procollagen	[39]
ADAMTS-3	Procollagen II	Processing of N-propeptide of procollagen	[40]
ADAMTS-4	Aggrecan, versican, brevican	Cleavage of proteoglycan core proteins	[20,52,50]
ADAMTS-5	Aggrecan	Cleavage of aggrecan core protein	[21]
ADAMTS-8		Anti-angiogenic	[45]
ADAMTS-13	von Willebrand factor	Reduced activity results in thrombotic Thrombocytopaenic purpura	[43]
ADAMTS-14	Procollagen I	Procollagen N-proteinase	[41]

ADAMTS, a disintegrin and metalloproteinase domain with thrombospondin motif.