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CHO cells forced into mitosis in the presence of incompletely replicated DNA show a high percentage of abnormal mitotic spindles
| Percentage of cells in mitosis | Percentage of mitotic cells that are abnormal | Percentage of interphase cells with more than two centrosomes | |
|---|---|---|---|
| Control | 2% | 1% | 0% |
| 18 h HU | 0% | 1% | |
| 18 h HU + 4 h HU and caffeine | 3% | 70% | 2% |
| 4 h caffeine | 2% | 2% | 2% |
| 6 h HU | 0% | 2% | |
| 6 h HU + 4 h HU and caffeine | 1% | 31% | 2% |
| 6 h HU and 8 h recovery | 2% | 1% | 2% |
