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Chemotaxis and trans-endothelial cell migration to CSF-1 is defective in cyclin D1-/- bone marrow macrophages. (A). A Boyden microchemotaxis chamber was used to assess guided chemotaxis to CSF-1 with WT and cyclin D1-/- BMMs. (B). Transendothelial migration of BMMs was assessed using a pulmonary endothelial monolayer. Wild-type and cyclin D1-deficient BMMs were exposed to CSF-1 at the concentrations indicated.
