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(A) Structure of HA14-1 (ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate), a nonpeptidic organic compound that binds Bcl-2 protein. Note that HA14-1 has two chiral centers (marked by asterisks) located at the C4 position and the carbon atom attached with the cyano group, respectively. (B) Structural model for the complex of HA14-1 with the Bcl-2 surface pocket as predicted by computer docking calculation.
