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Hypothetical model of the transformation system in T. thermophilus HB27. Two possible DNA binding sites are indicated; they are at the tip of the pilus structures (a) and close to the potential ring-like structure consisting of secretin-like subunits in the outermost layer (b). dsDNA, double-stranded DNA; ssDNA, single-stranded DNA; Nuc, postulated but unidentified competence-specific endonuclease which cleaves double-stranded DNA upon transport through the inner membrane.
