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Survival of CVB4-V-infected, IL-12-treated mice. Infected mice treated with 500 ng of IL-12 (dashed line) or vehicle alone (solid line) were monitored daily for 2 weeks. Mice that became moribund were euthanized immediately. Each group contained 20 to 21 mice. Treatment with 500 ng of IL-12 significantly (P < 0.001) increased the survival of CVB4-V-infected mice.
