FIG. 3.

Histopathology of pancreatic tissues from CVB4-V-infected mice treated with either IL-12 or IFN-γ. Pancreata were harvested at 14 days postinfection, processed for routine histology, and stained with hematoxylin and eosin. (A) Uninfected; (B) CVB4-V-infected; (C) CVB4-V-infected and treated with 500 ng of IL-12; (D) CVB4-V-infected and treated with 100 ng of IFN-γ on multiple days (0.5, 1, and 2) after infection. Labeling: A, acini; I, islet of Langerhans; L, lymphocytic infiltrate; AN, acinar cell necrosis. Magnifications: ×234 for panels A, B, and C; ×117 for panel D.