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. 2003 Aug;77(15):8299–8309. doi: 10.1128/JVI.77.15.8299-8309.2003

FIG. 8.

FIG. 8.

HCV core-mediated enhancement of MHC class I expression has no effect on recognition by HCV-specific CTL. The cytotoxicity of an HCV NS3-specific CTL clone (peptide 1073-1081) against mock-transfected control and HCV core- and ORF-transfected HepG2 target cells in two experiments was analyzed (A and B). Target cells were left untreated (white bars) or preincubated with 1 μg of the NS31073-1081 peptide per ml (black bars). The NS3-specific clone was used at an effector-to-target (E/T) cell ratio of 5:1. Mean values ± standard deviations of triplicate samples are shown (A). Titration of the NS3-specific CTL clone against untreated (open symbols) and NS3-pulsed (1 μg/ml) HepG2 mock-transfected control or HCV core- and ORF-transfected cells (B). The data shown are mean values of triplicate samples.