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Comparison of clinical isolates (wt) and their drug-resistant variants with NA mutations (mut) by focus reduction assay. (a) A/Sydney/5/97-like virus (H3N2) and its variant with NA-substitution R292K assayed in MDCK-SIAT1 cells. Infection time was 40 h. (b) A/Wuhan/359/95-like virus (H3N2) and its variant with NA mutation E119V assayed in parallel in MDCK cells (two upper rows) and in MDCK-SIAT1 cells (two lower rows). Infection time was 48 h.
