FIG. 1.

HPV16 infection reduces the number of LC resident in the epidermis and the remaining LC have a less dendritic morphology. (A) S100 positive LC cells were enumerated in cervical epidermis that was identified as HPV16⁺ by the presence of E4 staining (n = 8) and in cervical epidermis from normal individuals (n = 8). The numbers of LC/square millimeter are presented, and the mean ± the standard error of the mean is shown. The asterisk indicates a statistically significant difference (Mann Whitney test) between the two groups (P = 0.015). (B and C) LC in HPV16 epidermis are generally morphologically less dendritic (B) than LC in normal skin (C). Bar, 10 μm.