TABLE 3.

Immune responses of vaccinated macaques correlated with reduced viral burdens^a

Cellular or humoral response by viral burden group	P value at:
	Peak prechallenge	Time of challenge	Wk 2 postchallengeb	Wk 4 postchallengeb
Cellular response
Envelope
Intermediate versus high	0.057	0.057
Low plus intermediate versus high	0.024
Low versus intermediate versus high			0.028	0.014
Gag
Low versus intermediate versus high			0.0039	0.0013
Paired Gag and envelope
Low plus intermediate versus high	0.051
Humoral response
Binding Antibody to gp120: Nasal IgG
Low versus high		0.029
Low plus intermediate versus high		0.028
Paired Nasal IgG plus IgA
Low versus high		0.029
Low plus intermediate versus high		0.032
Paired vaginal plus nasal IgG
Low versus high		0.029
Low plus intermediate versus high		0.042
Paired serum, nasal, and vaginal IgG
Low versus high		0.029
Low plus intermediate versus high		0.057
Neutralizing antibody
Low versus high		0.057

^aP values <0.05 are considered statistically significant. We also report comparative outcomes approaching statistical significance.

^bPostchallenge comparisons include both immunized and control non-Mamu-A∗01 macaques.