TABLE 2.

Coreceptor use and 2D7 neutralization summary^a

Virus	Coreceptor	% Controlb (SE)
Q23A4	CCR5	52.6 (6.7)
Q23B6	CCR5	58.4 (4.7)
Q45D5	CCR5	36.2 (8.9)
Q45D6	CCR5	37.0 (6.5)
Q47M1	CCR5	40.7 (3.8)c
Q47S6	CCR5	94.8 (6.3)

^aRatios of infected cells are as follows: A4/B6, 0.54; D5/D6, 1.00, M1/S6, 0.38. The number of cells infected with the chimeras is significantly different for A4/B6 and M1/S6 (Student's two-tailed t test, P < 0.01.). The number of infected CCRS-GHOST cells was determined by flow cytometry for each of the clade A chimeras in eight replicate experiments. The data are displayed as the ratio of the mean number of infected cells for each virus pair.

^bThe percent control is the number of cells infected in the presence of 2D7 (10 μg/ml) divided by the number of cells infected in the presence of the control antibody. Mean percent control and standard error were determined from four replicate experiments.

^cThe percent of cells infected with Q47M1 is significantly different from the percent of cells infected with Q47S6 in the presence of 2D7 (10 μg/ml) relative to respective controls (Student's two-tailed t test, P < 0.01).