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The enlargements show the region containing residues Tyr106 to Glu156 of human AdoHcyase. Mutated amino acids or residues involved in enzymatic activity and hydrogen-bonding are represented with side chains. Existing hydrogen bonds are shown as broken lines. (a) Wild-type; (b) p.Y143C is lacking hydrogen bond between Tyr143 and Glu115; (c) p.E115L is lacking hydrogen bond between Tyr143 and Leu115.
