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Values in parentheses are percentage of wild-type. Truncation mutant p.W112stop is completely inactive. N/A, not assessed.
| Enzymatic activity (μmol·min−1·mg−1) | ||||
|---|---|---|---|---|
| Km (μM) Hydrolysis | Hydrolysis | Synthesis | NAD/tetramer | |
| Wild-type | 15.09 | 0.748 (100%) | 1.23 (100%) | 3.5 |
| p.Y143C | 11.0 | 0.185 (25%) | 0.42 (34%) | 3.1 |
| p.E115L | 11.47 | 0.500 (68%) | 0.75 (61%) | 4.6 |
| p.W112stop | N/A | N/A | N/A | N/A |
