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Failure of eyelid closure in MEKK1−/− mice. Mice that are MEKK1−/− are born with open eyelids. Wild-type littermates are born with closed eyes that remain closed for approximately 2 wk after birth. Two MEKK1−/− and two wild-type pups from different litters are shown. The open eyelid phenotype has a 95% penetrance in MEKK1−/− animals.
