Table I.
Top 24 differentially expressed genes in cell lines (K562, NB4, HL60) compared with clinical samples (CML, APL, AML M5).
| Rank | Probeset Id | Gene symbol | Log 2 fold change | Adjusted P-value | Gene title |
|---|---|---|---|---|---|
| 1 | 203820_s_at | IMP-3 | 3·9 | 1·2 × 10−15 | IGF-II mRNA-binding protein 3 |
| 2 | 209120_at | NR2F2 | 3·3 | 4·0 × 10−14 | Nuclear receptor subfamily 2, group F, member 2 |
| 3 | 218976_at | DNAJC12 | 3·3 | 4·9 × 10−13 | DnaJ (Hsp40) homologue, subfamily C, member 12 |
| 4 | 205194_at | PSPH | 2·3 | 8·9 × 10−12 | Phosphoserine phosphatase |
| 5 | 219371_s_at | KLF2 | −3·9 | 1·7 × 10−11 | Kruppel-like factor 2 (lung) |
| 6 | 209434_s_at | PPAT | 2·1 | 2·1 × 10−11 | Phosphoribosyl pyrophosphate amidotransferase |
| 7 | 208961_s_at | COPEB | −3·5 | 2·9 × 10−11 | Core promoter element binding protein |
| 8 | 204228_at | PPIH | 2·1 | 3·7 × 10−11 | Peptidyl prolyl isomerase H |
| 9 | 205394_at | CHEK1 | 2·1 | 5·2 × 10−11 | CHK1 checkpoint homologue |
| 10 | 214155_s_at | LOC113251 | 1·8 | 8·8 × 10−11 | c-Mpl binding protein |
| 11 | 213435_at | SATB2 | 2·7 | 8·8 × 10−11 | SATB family member 2 |
| 12 | 219006_at | C6orf66 | 2·3 | 2·2 × 10−10 | Chromosome 6 open reading frame 66 |
| 13 | 208763_s_at | DSIPI | −2·8 | 2·3 × 10−10 | Delta sleep inducing peptide, immunoreactor |
| 14 | 219479_at | KDELC1 | 1·9 | 7·2 × 10−10 | KDEL (Lys-Asp-Glu-Leu) containing 1 |
| 15 | 203696_s_at | RFC2 | 1·5 | 7·2 × 10−10 | Replication factor C (activator 1) 2, |
| 16 | 209406_at | BAG2 | 3·0 | 1·1 × 10−9 | BCL2-associated athanogene 2 |
| 17 | 209891_at | Spc25 | 2·0 | 1·1 × 10−9 | Kinetochore protein Spc25 |
| 18 | 203281_s_at | UBE1L | −1·4 | 1·7 × 10−9 | Ubiquitin-activating enzyme E1-like |
| 19 | 204795_at | PRR3 | 1·3 | 2·3 × 10−9 | Proline rich 3 |
| 20 | 209832_s_at | CDT1 | 3·0 | 2·3 × 10−9 | DNA replication factor |
| 21 | 222024_s_at | AKAP13 | −2·7 | 4·3 × 10−9 | A kinase (PRKA) anchor protein 13 |
| 22 | 209900_s_at | SLC16A1 | 2·7 | 4·3 × 10−9 | Solute carrier family 16 |
| 23 | 203957_at | E2F6 | 1·6 | 4·5 × 10−9 | E2F transcription factor 6 |
| 24 | 213320_at | HRMT1L3 | 1·8 | 4·6 × 10−9 | HMT1 hnRNP methyltransferase-like 3 |
Positive (or negative) mean log2 fold change indicates upregulation (or downregulation) in cell lines compared with fresh samples (refer to Table S1. for the extensive gene list).
P-values were adjusted to account for multiple testing with a false discovery rate approach (Benjamini & Hochberg, 1995).