Figure 1.

An example of a functional module detected by STRING. The module encompasses the prototypic phosphate-regulon, an active uptake-system for inorganic phosphate found in most, but not all, prokaryotes (24). (A) Network view. Green lines connect proteins which are associated by recurring neighborhood, blue connections are inferred by phylogenetic co-occurence, and red lines indicate gene-fusion events; line thickness is a rough indicator for the strength of the association. The visualization shows that the module is composed of two sub-modules: The larger module to the right contains the structural and immediate regulatory molecules of the transporter; the two proteins to the left form a two-component regulator system controlling the transcription of the other components in response to phosphate starvation. (B) Score summary view. Association scores are highest among structural components. (C) Evidence view. A subset of the full evidence is shown, visualizing the three types of genomic context links.