Table 1.
Genotype | % 3-83Ig+* | % λ+* |
---|---|---|
3-83Hi/+; 3-83ki/+; H-2d† | 22.1 ± 7.3 (n = 4) | 31.4 ± 4.0 (n = 7) |
3-83Hi/+; 3-83ki/+; H-2d; CD45−/−‡ | 76.2 ± 21.7 (n = 3) | 13.4 ± 4.2 (n = 3) |
3-83Hi/Hi; 3-83ki/ki; H-2d; BALB/c§ | 90.6 ± 5.5 (n = 6) | 3.8 ± 0.7 (n = 4) |
3-83Hi/Hi; 3-83ki/ki; H-2d; BALB/c × C57BL/6 × 129 | 71.9 ± 6.3 (n = 6) | 17.8 ± 7.6 (n = 6) |
3-83Hi/Hi; 3-83ki/ki; H-2b; BALB/c × C57BL/6 × 129 | 8.8 ± 3.2 (n = 4) | 52.9 ± 8.3 (n = 4) |
Wild-type BALB/c × C57BL/6 | 3.7 ± 2.7 (n = 8) | 4.0 ± 0.2 (n = 7) |
*Frequencies of 3-83+ and λ+ cells are calculated, respectively, in the IgM+ and B220+ (CD22+ for CD45−/− mice) populations.
†Mice on BALB/c or mixed (BALB/c × C57BL/6 × 129) background.
‡Mice on mixed (BALB/c × C57BL/6 × 129) background.
§Mice with or without Jκ3-5 segments downstream of the 3-83k insertion.