Table I. WAVE2 deficiency results in embryonic lethality during mid-gestation.
| Gestational agea | +/+ | +/neo | neo/neo | Resorbed | Total |
|---|---|---|---|---|---|
| Neonate/birth | 45 | 81 | 0 | nd | 126 |
| >E13 | 17 | 23 | 0 | 10 | 50 |
| E12–E12.5 | 2 | 4 | 1 | 2 | 9 |
| E11.5–E12 | 11 | 18 | 10 | 3 | 42 |
| E9.5–E11.5 | 9 | 16 | 11 | 0 | 36 |
| E7.5–E8.5 |
5 |
14 |
7 |
0 |
26 |
| Gestational ageb |
+/+ |
+/– |
–/– |
Resorbed |
Total |
| Neonate/birth | 23 | 51 | 0 | nd | 74 |
Live pups and embryos were genotypes by Southern blot analyses of yolk sac or tissue from embryos.
aOffspring from WAVE2+/neo matings;
bOffspring from WAVE2+/– matings; nd, not determined.