Fig. 3. The thoracolumbar kyphosis in HIP1^–/– mice does not result from a congenital skeletal defect or dysplasia. (A) The presence of a thoracolumbar kyphosis is evident in X-rays from a 7-month-old HIP1 (–/–) mouse in comparison with its wild-type (+/+) littermate. Both mice are shown in lateral (top) and anteroposterior (bottom) views. (B) No congenital skeletal defect or dysplasia is evident in Alzarin Red-stained skeletons prepared from a HIP1 (–/–) mouse at 7 months of age in comparison with its wild-type (+/+) littermate.