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. 2003 Jul;14(7):2665–2676. doi: 10.1091/mbc.E02-12-0832

Figure 6.

Figure 6.

Infusion of soluble laminin-1 promotes neurodegeneration in tPA-deficient mice. TPA-deficient mice were infused with mouse laminin-1, plasmin-digested laminin-1, or buffer for 5 d, and then kainate was injected. Two days after kainate injection, the mice were killed and brain sections were prepared. The brain sections were processed for anti-laminin-1 immunostaining (A, D, and G) or cresyl violet staining (B, C, E, F, H, and I). Infusion of soluble laminin-1 or plasmin-digested laminin-1 promoted neurodegeneration in tPA–/– mice (E, F, H, and I). Higher magnification of the boxed areas in B, E, and H is shown in C, F, and I, respectively. Ln, laminin immunostaining; CV, cresyl violet staining. Bar in H for A, B, D, E, G, and H, 500 μm; bar in I for C, F, and I, 25 μm.