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. Author manuscript; available in PMC: 2007 Mar 1.
Published in final edited form as: Am J Physiol Heart Circ Physiol. 2005 Sep 23;290(3):H948–H958. doi: 10.1152/ajpheart.00868.2005

Fig 7. Scheme for the enhanced AA release.

Fig 7

Upon thrombin activation, Gαq and Gα12/13 signaling pathways converge to empty Ca2+ stores and redirect subsequent PKCα dependent Ca2+ entry. The elevation of [Ca2+]i enhances Ca2+-dependent PLA2 activation initiated by B2 R agonists and increases release of AA.