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. 2000 Jun 20;97(13):7458–7463. doi: 10.1073/pnas.97.13.7458

Figure 5.

Figure 5

Anti-CD40L antibody treatment reduces the extent of atherosclerotic lesions in the abdominal aorta of hypercholesterolemic mice. Ldlr-deficient mice consumed a high-cholesterol diet for 13 weeks before treatment with either rat IgG, saline, or anti-CD40L antibody (α-CD40L) for 13 weeks during continued high-cholesterol diet. Cross sections of the longitudinally cut abdominal aortae from three mice (proximal to the renal artery bifurcation) are shown.