Figure 10.

Effect of WT or mutant K18, and/or WT or mutant K20, overexpression on keratin filament organization in transgenic mouse small intestine. The schematic shows the impact on keratin filament organization upon overexpressing WT or R80H K20 (x-axis), or WT or R89C K18 (y-axis), compared with control nontransgenic FVB/n mice (shown in A, which also includes codes for the cell types shown in B–I). Keratin organization in epithelial cells of the small intestine is illustrated by the two typical patterns: 1) normal-looking filaments; and 2) a mixture of dots, cables, and short filaments.