Table 1.
Amino acid alignment of human, rat, and mouse K20 sequences
| Human | MDFSRRSFHRSLSSSLQAPVVSTVG-------MQRLGTTPSVYGGAGG |
| Rat | MDFSRRSFHRSLSSSSQGPALSTSGSLYRKGTMQRLGLH-SVYGG-WR |
| Mouse | MDFSRQSFHRSLSSSSQGPALSMSGSLYRKGTVQRLGAAPSVYGGAGG |
| ***** ********* * * * * **** ***** | |
| Human | RGIRISNSRHTVNYGSDLTGGGDLFVGNEKMAMQNLNDRLASYLEKVR |
| Rat | HGTRISVSKTTMSYGNHLSNGGDLFGGNEKLAMQNLNDRLASYLEKVR |
| Mouse | HGTHISVSKAVMSYGGDLSNGSDLFGGNGKLAMHNLNDRLANYLEKVR |
| * ** * ** * * *** ** * ** ******* ****** | |
| Human | TLEQSNSKLEVQIKQWYETNRPRAGRDYSAYYRQIEELRSQIKDAQLQ |
| Rat | SLEQSNSKLEAQIKQWYETNAPSTIRDYSSYYAQIKELQDQIKDAQIE |
| Mouse | SLEQSNCRLEAQIKQRYETNAPSTIRDYSSYYAQIKELQNQVKDAQVQ |
| ***** ** **** **** * **** ** ** ** * **** | |
| Human | NARCVLQIDNAKLAAEDFRLKYETERGIRLTVEADLQGLNKVFDDLTL |
| Rat | NARCVLQIDNAKLAAEDFRLKFETERGMRITVEADLQGLSKVYDDLTL |
| Mouse | NAQCVLRIDNAKLAAEDFRLKFETERGMRIAVEADLQGLSKVYDNLTL |
| ** *** ************** ***** * ******** ** * *** | |
| Human | HKTDLEIQIEELNKDLALLKKEHQEEVDGLHKHLGNTVNVEVDAAPGLN |
| Rat | QKTDLEIQIEELNKDLALLKKEHQEEVEVLRRQLGNNVNVEVDAAPGLN |
| Mouse | QKTDLEIQIEELNKDLALLKKEHQEEVEVLRRQLGNNVNVEVDAAPGLN |
| ************************** * *** ************ | |
| Human | LGVIMNEMRQKYEVMAQKNLQEAKEQFERQTAVLQQQVTVNTEELKGTE |
| Rat | LGEIMNEMRQKYEILAQKNLQEAKEQFERQTQTLEKQVTVNIEELRGTE |
| Mouse | LGEIMNEMRQRYEVLAQKNLQEAKEQFERQSQTLQQQVTVNTEELKGFE |
| ** ******* ** *************** * ***** *** * * | |
| Human | VQLTELRRTSQSLEIELQSHLSMKESLEHTLEETKARYSSQLANLQSLL |
| Rat | VQVTELRRSYQTLEIELQSQLSMKESLERTLEETKARYASQLAAIQEML |
| Mouse | VQVTELRRTYQNLEIELQSHLSMKESLERNLEDVKARYASQLAAIQEML |
| ** ***** * ******* ******** ** **** **** * * | |
| Human | SSLEAQLMQIRSNMERQNNEYHILLDIKTRLEQEIATYRRLLEGEDVKT |
| Rat | SSLEAQLMQIRSDTERQNQEYNILLDIKTRLEQEIATYRRLLEGEDIKT |
| Mouse | SSLEAQLMQIRSDTERQNQEHNILLDIKTRLEQEIATYRRLLEGEDIKT |
| ************ **** * ************************ ** | |
| Human | TEYQLSTLEERDIKKTRKIKTVVQEVVDGKVVSSEVKEVEENI |
| Rat | TEYQLNTLEAKDIKKTRKIKTVVEEVVDGKVVSSEVKEIEENI |
| Mouse | TEYQLSTLEMKDIKKTRKIKTVVEEVVDGKVVSSEVKEIEESV |
| ***** *** ************ ************** ** |
The mouse sequence is presented as part of this study. The human and rat sequences were described previously (Moll et al., 1990; Chandler and Quaroni, 1993). * indicates identical amino acids. The percentage of identities at the amino acid level among the K20 sequences are human and rat, 80%; human and mouse, 78%; rat and mouse, 89%