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Effect of Y2−/− Y4−/− double knockout on bone morphology compared with no knockout, Y2−/− knockout, or Y4−/− knockout in male mice. Trabecular bone volume (A), trabecular number (B), trabecular thickness (C), cortical area (D), and cortical thickness (E) were determined. Data are means ± standard deviations for 6 to 14 mice per group. *, P < 0.05 versus control mice.
