TABLE 1.
Histomorphometric analysis of bone cells in distal femoral metaphysis in Y receptor knockout micea
| Mice | Osteoblast surface (% OS) | Osteoblast no. (/mm of OS) | Osteoid surface (% BS) | Osteoclast surface (% BS) | Osteoclast no. (/mm) |
|---|---|---|---|---|---|
| Control | 10.4 ± 4.1 | 9.5 ± 2.5 | 12.7 ± 5.8 | 8.0 ± 2.3 | 4.2 ± 1.2 |
| Y2−/− | 7.9 ± 2.7 | 7.3 ± 2.7 | 11.1 ± 4.4 | 6.4 ± 1.9 | 2.9 ± 0.6* |
| Y4−/− | 10.1 ± 3.7 | 5.0 ± 1.5* | 12.0 ± 4.6 | 9.4 ± 2.9 | 4.5 ± 1.7 |
| Y2−/− Y4−/− | 18.6 ± 5.9* | 10.8 ± 3.4 | 23.2 ± 8.1* | 14.1 ± 5.8* | 4.1 ± 1.1 |
a
Data are means ± standard deviations for 6 to 14 mice per group. *, P < 0.05 versus control. OS, osteoid surface; BS, bone surface.