Figure 4.

Immunohistochemical detection of myelin antigens during chronic inflammation caused by peripheral immunization with adenovirus in animals injected with first generation vectors into the brain. No loss of myelin basic protein immunoreactivity in the ipsilateral subcortical white matter or striatum was detected at day 120 in animals injected intrastriatally with RAd35 at day 0, and intradermally at day 60 with RAdHPRT. Thus, the chronic inflammation is not accompanied by loss of myelin specific proteins. (Bar = 1 mm.)