FIG. 9.

Hepatocytes of some smaller vti1b-deficient mice accumulated autophagic vacuoles and multivesicular bodies. (A) The numbers of early (Avi) and late (Avd) autophagic vacuole profiles per 100 μm² of cell area on thin sections were determined for hepatocytes isolated from wild-type (wt) and three different smaller vti1b-deficient (Ko) mice. The error bars represent standard errors of the mean. (B) Fusion profiles of autophagic vacuoles (arrows), as well as multivesicular bodies (∗), were more prominent in hepatocytes from vti1b^−/− mouse 101 (left) than in wild-type (right) hepatocytes. G, Golgi. Bar, 500 nm.