FIG. 1.

Identification of human hFis1, a homologue of the yeast mitochondrial outer membrane protein Fis1p. (A) Sequence alignment for human hFis1 and yeast Fis1p. The two proteins share 25% identity and 63% similarity in amino acid sequences. The C-terminal regions of both proteins contain a stretch with a putative transmembrane domain (underlines). (B) Fis1p (hFis1) is a transmembrane protein anchored at the outer mitochondrial membrane with its N-terminal region exposed to the cytoplasm and a short C-terminal tail in the intermembrane space.