Figure 1.

BBL22 induces human tumor cell apoptosis. DNA histograms indicate cell cycle kinetics of androgen-dependent LNCaP prostate cancer cells (A–C), androgen-independent PC3 prostate cancer cells (D–F), and the estrogen-receptor-negative HBL100 breast carcinoma line (G and H) before (0 h) and at various time points (24 h and 72 h) after treatment with 50 μM BBL22. The percentage of cells in G₁, S phase, and G₂/M are indicated. The sub-G₁ peak represents the apoptotic population. Data shown is representative of five independent experiments.