Table 1.
Murine phenotype | Treatment | α-gal A activity, nmol/h per mg protein
|
||
---|---|---|---|---|
BM cells (24 hr) | Progenitor colony cells (14 d) | Adherent LTBMCs (15 wk) | ||
Fabry | None (mock) | 7 ± 0 | 6 ± 0 | 19 ± 0 |
Fabry | pG1T/α-gal A | 1,630 ± 30* | 42 ± 2* | 290 ± 7* |
Fabry | pUMFG/α-gal A/FLAG | 2,310 ± 70*† | 720 ± 16*† | 790 ± 18*† |
Wild type | None (mock) | 2,170 ± 50 | 3,600 ± 140 | NE |
Activities were measured 24 hr, 14 days, or 15 weeks after the last transduction, as shown. NE, not examined. *, P < 0.0001 vs. Fabry (mock) group; †, P < 0.0001 vs. pG1T/α-gal A group.