Table 2.

α-gal A activity in BMMCs, PBMCs, and plasma in mice after ex vivo transduction and transplantation of syngeneic BMMCs

Group (no. of mice)	α-gal A activity
	BMMCs, nmol/hr/mg protein	PBMCs, nmol/hr/mg protein	Plasma, nmol/ hr/ml
Wild type: 12 weeks
Untouched (5)	420  ± 18	17  ± 1	2.4  ± 0.1
Knockout: 12 weeks
Untouched (4)	2  ± 1	1  ± 0	0.5  ± 0.1
1,100 rads–mock (5)	4  ± 1	1  ± 1	0.5  ± 0.1
550 rads–transduced (5)	360  ± 15*	34  ± 2*	9.4  ± 0.5*
1,100 rads–transduced (6)	75  ± 6*	370  ± 22*	3.2  ± 0.2*
Knockout: 26 weeks
1,100 rads–transduced (6)	190  ± 10*	250  ± 19*	3.7  ± 0.2*

*, P < 0.0001 vs. 1,100 rads–mock group (unpaired t test).