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Competition between the MutY protein and the MutHLS MMR system. (A) Misreplication at an A · T base pair leads to an A · C mispair that is corrected by the MutHLS MMR system but converted to a G · C pair by MutY. (B) Misreplication at a G · C base pair leads to an A · C mispair that is converted back to a G · C pair by both MutY and the MMR system.
