TABLE 2.
rpoB frequencies and notes of mutationsa
| Strain | Mean value (95% CL)b
|
|
|---|---|---|
| f (10−8) | μ (10−8) | |
| WTc | 7.6 (5.2-8.8) | 1.5 (1.1-1.7) |
| mutY mutant | 79 (68-90) | 11 (7.4-12) |
| ndk mutant | 570 (530-630) | 64 (60-70) |
| mutS mutant | 935 (848-1,110) | 120 (110-140) |
| ndk mutY mutant | 206 (126-280) | 26 (17-34) |
a
The rpoB mutation frequencies (f) per cell were calculated by dividing the median number of mutants by the average number of cells in a series of cultures, and the mutation rates (μ) per replication were calculated from these values by the method of Drake (5).
b
CL, confidence limits (3).
c
WT, wild type.