Structural organization and phylogenetic trees of GluA and GluC domains. Relevant clades of maximum-likelihood trees for the family 16 catalytic domain (open box) and CBM6 domain (striped box), with branch partition frequencies from a consensus tree of 1,000 likely trees near nodes, are shown. For the catalytic domain, the tree depicts the following (GenBank accession numbers in parentheses): Agrobacterium tumefaciens 1 endo-1,3-1,4-β-glycanase (NP_357049), Agrobacterium tumefaciens 2 endo-1,3-1,4-β-glycanase (NP_534060), Bacillus circulans 1 glucan endo-1,3-β-glucosidase A1 (P23903), Bacillus circulans 2 glucan endo-1,3-β-d-glucosidase (JN0772), Caulobacter crescentus β-glucanase (NP_419199), Clostridium thermocellum 3 endo-1,3(4)-β-glucanase (T18265), GluA from L. enzymogenes β-1,3-glucanase (AY157838), GluC from L. enzymogenes β-1,3-glucanase (AY157840), “F. keratolyticus” endo-β-galactosidase (AF083896), Mesorhizobium loti endo-1,3-1,4-β-glycanase (NP_103892), O. xanthineolytica 1 β-1,3-glucanase (AAC44371), O. xanthineolytica 2 β-1,3-glucanase (AAC38290), Pyrococcus furiosus endo-β-1,3-glucanase (AAC25554), Rhodothermus marinus 1 endo-β-1,3-1,4-glucanase (P45798), Rhodothermus marinus 2 laminarinase (AAC69707), Sinorhizobium meliloti 2 endo-1,3-1,4-β-glycanase (CAB38101), Sinorhizobium meliloti 3 endo-1,3-1,4-β-glycanase (O33680), S. coelicolor 1 probable secreted glucosidase (T35164), S. coelicolor 2 putative secreted hydrolase (CAC14352), S. coelicolor 3 putative secreted hydrolase (CAC16455), S. sioyaensis endo-1,3-β-glucanase (AAF31438), T. tridentatus α-subunit of coagulation factor G (A49878), Thermotoga neapolitana laminarinase (CAA88008), and Thermotoga maritima laminarinase (NP_227840). For the CBM6 domain, the tree depicts the following (GenBank accession numbers, followed by residue region, in parentheses): C. mixtus A cellulase (AAB61462; 359 to 484), C. mixtus B cellulase (AAB61462; 492 to 620), GluC from L. enzymogenes β-1,3-glucanase (AY157840; 263 to 382), Pseudomonas sp. strain 1 chitinase (BAB79259; 414 to 533), Pseudomonas sp. strain 2 cellulase (BAB79288; 345 to 464), T. tridentatus A α-subunit of coagulation factor G (A49878; 414 to 534), and T. tridentatus B α-subunit of coagulation factor G (A49878; 551 to 672).