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. 2003 May 19;100(12):7015–7020. doi: 10.1073/pnas.0732060100

Fig. 1.

Fig. 1.

Representative images of the S. cerevisiae PDC molecules with ≈60 E1/E2 core (A and B) and a diagram of the domain organization of E2 showing its E1-binding site (D). The solid circle around the images in A and B corresponds to the approximate diameter of the large molecules in A (≈550 Å in diameter) and serves as an aid in determining the relative size of the smaller images (≈500 Å in diameter) in B. The images in A and B are representative of those used for the 3D reconstructions shown in Fig. 2 A and B, respectively. The broken circle corresponds to the size of the smaller images in B and shows that the projections (C) of the reconstruction in Fig. 2B are representative of the same orientation of molecules in B. These images have a similar size and protein density distribution in the E1 outer shell. The E1 molecules are bound to the E2 central core by its E1-binding domain in the inner linker as illustrated in D.