Table 3. Effects of probucol on RBC parameters in apoE KO and dKO mice.

Genotype/drug treatment	Hematocrit, %	Mean corpuscular volume, fL	Reticulocytes, % of total RBCs
apoE KO
None (n = 8)	52.5±2.1	57.6±0.5	2.8±1.2
Probucol (n = 3)	49.8±1.5	54.2±2.1	4.1±0.8
dKO
None (n = 6)	34.2±1.7	84.1±4.1	100±0
Probucol (n = 3)	50.8±2.4	54.2±2.3	4.1±0.5

All animals were 4-6 weeks old, except one each of probucol-treated dKO and apoE KO that were 6 months old. All values are means ± standard deviations. All of the values from the untreated dKO mice were significantly different from those from the other three groups (P < 0.0001 for mean corpuscular volume and percentage reticulocytes; P < 0.001 for hematocrit). Normal mouse reticulocyte counts range from 2% to 6%. Data for untreated animals are from ref. 22