Fig. 1.
Design of the study and composition of the experimental groups in the two sets of experiments. Time 0 refers to the day of the i.c.v. injection of 192IgG-saporin; an osmotic minipump connected to an i.c.v. catheter was implanted for EGF and bFGF administration and then replaced for NGF delivery. A diet enriched with retinoic acid (RA) was then supplied. Animals were tested for behavioral performance at the indicated time intervals and all animals were then killed for biochemical, molecular, and morphological analysis.