Table 2. Endplate studies.

	Controls	Patient
[125I]α-bgt binding sites/EP	12.82±0.79 E6 (13)	11.51 E6
Resting membrane potential, mV*	-72.5±0.78 (75)	-75.5±1.4 (13 fibers)
EPP amplitude, mV†	ND	42.6±5.05 (12)
Quantal release at 1 Hz‡	31±1 (190)	36±4.3 (12)
MEPP amplitude, mV§	1.00±0.025 (165)	1.17±0.08 (9)
Single-channel opening bursts¶
τ2, ms	0.12±0.012 (32)	0.067±0.0078 (3)
Area	0.16±0.014	0.16±0.025
τ2, ms	3.04±0.175 (34)	2.91±0.32 (3)
Area	0.85±0.015	0.84±0.024

Values indicate mean±SEM. Measurements were made at 30°C for MEPPs and EPPs and at 22°C for single-channel recordings. Numbers in parentheses indicate number of subjects for [¹²⁵I]α-bgt binding sites/EP and number of fibers or EPs for other measurements

^*Measured with 10-15 MΩ glass microelectrodes

^†Corrected for a resting membrane potential of -80 mV and nonlinear summation

^‡Corrected for a resting membrane potential of -80 mV, nonlinear summation, and non-Poisson release

^§Corrected for resting membrane potential of -80 mV and for a fiber diameter of 50 μm

^¶ACh, 1 μM; pipette potential, 80 mV; bandwidth, 5.8 kHz