Table 2.

Pharmacological characterization of L305Q AT_1A mutant

	Ki, nM
	WT	L305Q
AngII	0.77  ± 0.38	0.67  ± 0.25
Sar1-Ile8-AngII	0.10  ± 0.04	0.24  ± 0.08
CGP42112A	540  ± 60	99  ± 42*
L162,313	51  ± 5	20  ± 3*
Losartan	5.9  ± 1.7	3.7  ± 0.4

Results are mean ± SEM of three independent experiments. 

^*Significantly different from WT (P < 0.01).