Table 1. Thermal stability of oligonucleotide complexes (50 mM sodium cacodylate, 100 mM NaCl, 10 mM MgCl2).
Oligonucleotide system | Complex composition | Tm (°C) (±0.5°C) | |
---|---|---|---|
pH 7.0 | pH 5.0 | ||
System I | TDI-D | 48.2 | 49.0a |
X-TDI-X | 47.1 | 71.0 | |
TRI-D | 58.7 | ||
X-TRI-X | 40.7 | 71.1 | |
System II | TDII-Dap | 44.6 | |
Xp-TDII-Xap | 38.4 | 63.8 | |
TRII-Dap | 49.2 | ||
Xp-TRII-Xap | 36.0 | 62 |
aThe oligonucleotide ratio at pH 5 was D:TDI = 2:1.