Table 1. Comparison of PPAR sequences.
Position in human hPPARγ | PPARα | PPARγ | PPARδ | ||||
---|---|---|---|---|---|---|---|
|
Human |
fr074373 |
fr087148 |
Human |
fr054267 |
Human |
fr07671 |
Helix3-289 | Ser | Ser | Ser | Ser | Ser | Thr | Thr |
Helix5-323 | Tyr | Tyr | Tyr | His | Ile | His | His |
Helix10-449 | His | His | His | His | His | His | Asn |
HelixAF2-473 | Tyr | Tyr | Tyr | Tyr | Met | Tyr | Tyr |
Italics specify amino acids that differ from the consensus. Bold specifies amino acids predicted to prevent fatty acid ligand binding.