TABLE 2.
Effects of a lethal dose of LPS from serovar Abortus-equi in galactosamine-treated C57BL/10ScSn mice after MALP-2 pretreatment
| MALP-2 dose (μg/mouse) for i.p. pretreatment | Time (h) before challenge | No. dead after i.v. challenge with 50 ng of LPS/mousea |
|---|---|---|
| None | 7 | |
| 0.4 | 5 | 7 |
| 0.4 | 24 | 6 |
| 2 | 5 | 7 |
| 2 | 24 | 6 |
| 10 | 5 | 3 |
| 10 | 24 | 7 |
a
Seven mice were in each group. Simultaneously with the LPS challenge, mice were given 20 mg of galactosamine. Death in unprotected mice occurred within 6 to 8 h after LPS application.