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. 2003 Aug;71(8):4498–4505. doi: 10.1128/IAI.71.8.4498-4505.2003

FIG. 4.

FIG. 4.

Protection against pneumococcal infection after immunization with PspA/Rx1 fragment JAS218. Each point represents the results of a single mouse. P values were calculated from comparison of days to death between immunized and nonimmunized groups by the Mann-Whitney U test. No P values were given if the value was ≥0.05. The only exception is the value marked by an asterisk, which was 0.032 when comparison of live and dead mice was conducted with the Fisher exact test. This difference was not significant by the Mann-Whitney U test. The value provided was calculated by comparison of live with dead mice. (A) CBA/N mice were immunized with JAS218. After a booster immunization, the mice were infected with 270 CFU of TIGR4, 320 CFU of WU2, or 270 CFU of BR6.1. (B) BALB/c mice were immunized with JAS218. After a booster immunization, the mice were infected with 2.5 × 106 CFU of TIGR4, 1.0 × 106 CFU of WU2, or 1.1 × 106 CFU of BR6.1.